Paralogous genes are those genes which are a result of duplication within the same species. Protein interactions and their specificities have been used for swapping as well as designing mutations.
Pitarch B.(2021) in their recent work have used conserved protein residues obtained as a result of multiple sequence alignment along with the information on their interactome to detect the so called conserved protein residues in paralogous genes. Information on interaction of proteins is used for the pairwise alignment of proteins. The results have been validated for RasH gene family.
The information on this work is available at the following URL:http://csbg.cnb.csic.es/pazos/Xdet/
Reference:
Pitarch B. et al. (2021) Protein residues determining interaction specificity in paralogous families. Bioinformatics 37(8):1076-1082