Finding evolutionary clusters and inferring from them has been of interest to biologists for a long time. The studies has been limited to the conserved elements that are present in genes involved in networks of secondary metabolites.
Houben M. M. et al.(2020) in their studies have developed a python based software tool which predicts the evolutionary conserved genes irrespective of their location and function.
The tool is available at the following URL:https://github.com/Gabaldonlab/EvolClust/
Reference:
Houben M. M. et. al.(2020) EvolClust: Automated inference of evolutionary conserved gene
clusters in eukaryotic genomes.Bioinformatics 36(4):1265-1266.