Protein modelling has been of great importance in drug Development. It has been found that proteins exhibiting tandem domains show aggregation and misfolding. Various methods have been proposed to overcome such a problem but no method so far has been proved to be fully free from errors. To address this issue Lafita A. et al.(2019) have come up with a new software tool TADOSS (Tandem Domain Swap Stability predictor).
The software picks up domains in proteins which can be swapped and performs the domain swapping. It has been found to be of extreme importance in areas where there is increased need of swapping, in particular regions of proteins which form hinge loops.
The source code is available at github https://github.com/lafita/tadoss
Reference:
Lafita A. et al.(2019)TADOSS:Computational estimation of tandem domain swap stability. Bioinformatics 35(14):2507-2508
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