Understanding the mechanisms and functions of population diversification requires revealing structural differences both within and between groups. Current structural variation visualization methods are limited in their capacity to incorporate annotations and may necessitate time-consuming figure preparation.
In order to automatically visualize pairwise alignments of several annotated sequences as dot plots merged into a single matrix, the authors created PatchWorkPlot. PatchWorkPlot makes it possible to investigate the locations, breakpoints, and structural variation architectures of two or more sequences. The program generates high-resolution, publication-ready figures and allows users to customize the visualization parameters. PatchWorkPlot streamlines the creation of intricate plots for a variety of scenarios, from single loci to extensive comparative studies, and drastically cuts down on human labor.
PatchWorkPlot is available at github.com/yana-safonova/PatchWorkPlot.
Reference:
Pospelova M. et. al. (2025)PatchWorkPlot: simultaneous visualization of local alignments across multiple sequences.Bioinformatics 41(10): btaf504
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