Use of filtered spaced word matches as anchor points for accurate multiple alignment of distantly related genome sequences

                Local homology search tools are used for aligning sequences.The methods identify anchor points which are used to work out local  alignments of input sequences.Suitable anchor points serve as important landmarks to enhance speed and sensitivity of genome alignments.
                In a recent study Leimeister et. al.(2019) have used filtered spaced word matches to produce these anchor points in genome alignments. They have generated a binary pattern for match and don’t care position. A standard X-drop algorithm is then used for the alignments which have score above the threshold value.The program is available at the following URL:http://spacedanchor.gobics.de
Reference:
Leimeister C.A.et.al.(2019)Accurate multiple alignment of distantly related genome sequences using filtered spaced word matches as anchor points.Bioinformatics 35(2): 211-218.