MotEvo software program is freely available at swiss regulon portal. The url of the website is www.swissregulon.unibas.ch.This software is based on bayesian probabilistic method. Regulatory binding sites are predicted by doing a multiple alignment of the phylogenetically related sequences.You can download the software by clicking on the MotEvo link given on the website.Example files are given in the software suite that you will download from the website.A user manual is also given. The program is compiled using c compiler.You can contact erik.vannimwegen@unibas.ch for MotEvo.
Ref:Erik van Nimwegen et al.(2012)MotEvo: integrated Bayesian probabilistic methods for inferring regulatory sites and motifs on multiple alignments of DNA sequences 28(4)487-494.