A lot of work involving sequence analysis is done using Hidden Markov Models. Aphid is a software package written in R language. It utilizes Hidden Markov Models.The aphid package is an advancement or adds on to the SAM and HMMER packages. It can be used to import, plot and train HMM models.
The package can be downloaded from the following website – https://github.com/shaunpwilkinson/aphid
Reference:
Wilkinson S.P. (2019) aphid : an R Package for analysis with profile hidden markov models. Bioinformatics 35(19):3829-3830